EPAS1 Is Required for Spermatogenesis in the Postnatal Mouse Testis1
نویسندگان
چکیده
منابع مشابه
SOHLH2 is essential for synaptonemal complex formation during spermatogenesis in early postnatal mouse testes
Spermatogenesis- and oogenesis-specific helix-loop-helix transcription factor 2 (SOHLH2) is exclusively expressed in germ cells of the gonads. Previous studies show that SOHLH2 is critical for spermatogenesis in mouse. However, the regulatory mechanism of SOHLH2 during early spermatogenesis is poorly understood. In the present study, we analyzed the gene expression profile of the Sohlh2-deficie...
متن کاملMll5 Is Required for Normal Spermatogenesis
BACKGROUND Mll5 is currently a member of the Mll family of SET domain histone methyltransferase proteins but studies have also showed that it could be part of the SET3 branch of proteins. Recently, constitutive knock out animal studies have shown that Mll5 is required for proper haematopoietic stem cell differentiation, and loss of Mll5 results in synthetic lethality for genome de-methylation. ...
متن کاملIs FSH required for adult spermatogenesis?
From the *Division of Reproductive Biology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland; jDepartment of Obstetrics/Gynecology, University of Colorado Health Sciences Center, Denver, Colorado; .JDepartment of Biochemistry, Washington State University, Pullman, Washington; §Department of Physiology, Laboratory of Structural Biology, Southern Illinois Univ...
متن کاملFoxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis.
Spermatogonial stem cells (SSCs) capable of self-renewal and differentiation are the foundation for spermatogenesis. Although several factors important for these processes have been identified, the fundamental mechanisms regulating SSC self-renewal and differentiation remain unknown. Here, we investigated a role for the Foxo transcription factors in mouse spermatogenesis and found that Foxo1 sp...
متن کاملRad18 is required for long-term maintenance of spermatogenesis in mouse testes
Maintaining the integrity of spermatogenic stem cells is essential to transfer genetic information to a descendant. However, knowledge of maintenance of genetic stability in stem cells is still limited. RAD18 is critical for postreplication repair through mono- and multi-ubiquitination of proliferating cell nuclear antigen (PCNA) to maintain genomic stability. Mammalian RAD18 is highly expresse...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2010
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.109.079202